SYNTHESIS OF OCTYLAMINE
- A mixture of 1-bromooctane (19.3g, 0.1 mol),
hexadecyltributylphosphonium bromide (5.1g, 0.01 mol), sodium azide (16.2g,
0.25 mol) and water (50 ml) is stirred at 80 °C for 8 hours.
- The aqueous phase
is carefully removed, the organic phase is diluted with toluene (15.5 ml), and
then a solution of sodium borohydride (11.7g, 0.3 mol) in water (30 ml) is
added in 30 minutes.
- The mixture is stirred at 80 °C for 16 hours.
- The layers
are separated and the organic phase is extracted with 10 per cent hydrochloric
acid.
- The catalyst is recovered from the organic phase by removal of the
solvent and is reused as isolated. Basification of the acid phase and
extraction with ether affords octylamine, 11.4g (88%), b.p. 172-174 °C.
No comments:
Post a Comment
We specialize in producing high value chemicals. Besides our regular products, we strive to develop new products based on customer’s requirements. Our R&D center plays crucial role in handling complex chemistries and developing newer technologies. We respect intellectual property rights and have confidentiality agreement with various multi national companies. We undertake contract manufacturing of fine chemicals and advance intermediates of API’s.